Since the 90s of the last century, development green chemical products has become a trend in the development of chemical industry, and the polymerization of amino acid series products development also emerged from. In recent years, Japan, the United States and other developed countries have carried out the research of microbial fermentation gamma polyglutamic acid, the Japanese walk in the forefront of the world, which Meiji Seika has realized the gamma poly glutamic acid in commercial production, and gradually extended its application, and the gamma poly glutamic acid also has been rarely reported.
Gamma polyglutamic acid (PGA) is a by microbial synthesis of poly amino acids, has excellent biological compatibility and biodegradability, the in vivo degradation for glutamic acid directly absorbed and used as biomedical materials. In addition, because of strong water absorption of poly glutamic acid, easy modification, can be rapidly degraded in nature, will not cause environmental pollution, can be used in cosmetics, food and drug delivery.
The topic group for the production of poly glutamic acid is mostly used in Japan, the extraction process is very complex, the production cost is very high. Through natural selection and mutation, strains with independent intellectual property rights, combined with the optimization of the enzyme production mechanism and fermentation conditions, gamma poly glutamic acid concentration of generated 30 grams / liter above, the glutamate substrate conversion rate of 80% of the production level and production rate reached 25 grams / liter / hour. At the same time, the new technology will be used to separate the traditional means of separation and ultrafiltration membrane separation means to simplify the process, so that the yield of the product reached 80%, the product content of 99%. The preparation and application of gamma poly glutamic acid high water absorbent resin were studied, and the water absorption of high water absorbent resin with water absorption rate of 1600 g / g was obtained. According to reports, the resin is a kind of sand fixing vegetation eco friendly materials, and is currently the preliminary study on the agricultural application.
