Monthly Archives: July 2014

Hyaluronic acid Details

Glycosaminoglycans (formerly called mucopolysaccharides, amino polysaccharides and acidic polysaccharides) in the structure of the simplest kind, it is by repeating disaccharide units
GlcUA-β (1 → 3) -GlcNAc, with β-1,4 glycosidic linkage formed. In the body, often in free form or covalently (proteoglycan complexes) in the form of complexes present.
The surface of the molecule contains many hydrophilic groups, can draw their physical 1,000 to 10,000 times the volume of water, keeping the moisture of loose connective tissue is important; while the viscosity of the HA has a strong, and the joints with a vitreous Run wet and protection; well promote wound healing.
HA is present in the extracellular matrix of connective tissue of animals. Among them, the bovine vitreous, human umbilical cord and rooster combs are commonly used material extracted HA. HA is widely used in cosmetics, artificial joints, surgical lubricants and other products. United States Food and Drug Administration (FDA) approval in 2003 through the use of injection patches of skin wrinkles.

Glycine Use

[Use a]
For biochemical reagents, used in medicine, feed and food additives, fertilizer industry as a non-toxic agent decarbonization
[Use two]
For the pharmaceutical industry, biochemical tests and organic synthesis
[Uses three]
Glycine is mainly used as chicken feed nutritional additives.
[Uses four]
Also known as the amino acid glycine (aminoacetic acid), glycine ethyl ester hydrochloride intermediates in the synthesis of pyrethroid insecticides used in pesticide production, but also synthetic fungicide iprodione and solid glyphosate herbicide, another it is also used in fertilizers, pharmaceuticals, food additives, spices and other industries.
[Use five]
Nutritional supplements. Mainly used for flavoring and so on.
Flavored with alanine together for alcoholic beverages, the addition of: Wine 0.4%, 0.2% whiskey, champagne 1.0%. Others such as powdered soup about 2%; lees pickled foods 1%. Because it can to a certain extent was shrimp, cuttlefish flavor, can be used for sauces.
B. subtilis and E. coli have certain reproductive inhibition. It can be used as surimi products, preservatives such as peanut butter, add the amount of 1% to 2%.
Because glycine buffer having zwitterionic amino and carboxyl, so there is a strong cushioning. Taste for salt and vinegar can sense a dampening effect. Dosage salted products 0.3% ~ 0.7%, pickled goods 0.05% to 0.5%.
Antioxidant effect (using its metal chelation) added to butter, cheese, margarine extend the shelf life of 3 to 4 times. To make baked goods in lard stable, glucose 2.5% and 0.5% glycine. Adding 0.1% to 0.5% of wheat flour with the speed of cooking, and can play the role of flavoring. Medicine for antacids (hyperacidity), Muscular Dystrophy therapeutic agent antidotes. Synthetic materials also threonine amino acids.
According to the provisions of GB 2760-96 used as a spice.
[Uses six]
Used as a buffer for the preparation of tissue culture media, copper, gold and silver test, medicine for the treatment of myasthenia gravis and progressive muscular atrophy, hyperacidity, chronic enteritis, children and other high-proline hyperlipidemia disease.
[Purpose seven]
Treatment of myasthenia gravis and progressive muscular atrophy; treat excessive stomach acid ester disease, chronic enteritis (often in combination antacid); combination with aspirin, can reduce its stimulation of the stomach; treatment of children with high proline hyperlipidemia; as generate non-essential amino acid nitrogen source, adding a mixed amino acid injection.
[Uses eight]
The product is used as a solvent to remove carbon dioxide in the fertilizer industry. In the pharmaceutical industry, can be used as amino acid preparations, chlortetracycline buffer and as an anti-Parkinson’s disease drugs L- synthetic materials dopa, is ethyl imidazole intermediates, which itself is an adjunct therapy medicine, to treat neurological hyperacidity, gastric ulcer inhibiting excessive acid is also effective. Workers in the food industry for the synthesis of the wine, brewing products, meat processing and refreshing drink recipes and saccharin to-agent, as a food additive, glycine can be used alone as a condiment, but also with sodium glutamate, DL- alanyl acid, citric acid, etc. used in conjunction. In other industries, as a pH adjusting agent, added to the plating solution, or other amino acids used as starting materials. For biochemical reagents and solvents in organic synthesis and biochemistry.
[Purpose nine]
Metallochromic indicator, solvents.

Butyl Paraben Inspection

Clarity and color of solution to take this product 1.0g, 10ml ethanol dissolved, the solution should be clear and colorless; such as color, with a yellow or yellow-green on the 1st standard colorimetric solution (Appendix Ⅰ Ⅹ A first law), shall not be deeper.
Acidity solution 2ml under “Clarity and color of solution” item, namely ethanol 2ml, water, 5ml, shake, bromocresol green indicator solution add 2 drops of sodium hydroxide (0.1mol / L) titrated to was blue, consume titrant (0.1mol / L) should be not more than 0.1ml.
Chloride take this product 2.0g, add water 50ml, heated to 80 ℃, let cool, filtered; the filtrate 5.0ml, check (Appendix Ⅷ A) according to the law, with a standard solution of sodium chloride solution 7.0ml compare and contrast made​​, shall not be thicker (0.035%).
Sulfate take the above filtrate 25ml, according to inspection (Appendix Ⅷ B), potassium sulfate solution 2.4ml comparison with the standard control solution made ​​no thicker (0.024%).
Take some relevant material, plus the mobile phase and dilute containing 1mg per 1ml solution as the test solution; take Butylparaben reference amount, plus the mobile phase and dilute made per 1ml 0.01mg solution as the reference solution; another methylparaben and Ethylparaben amount, plus mobile phase and diluted into a mixed solution containing 0.01mg per 1ml of. High performance liquid chromatography (Appendix Ⅴ D) was measured. Octadecylsilane bonded phase silica as a filler; in 1% acetic acid – methanol (40:60) as the mobile phase; detection wavelength of 254nm. Take a mixed solution 20μl into the liquid chromatograph, record the chromatogram separation, Methylparaben Ethylparaben peak and peak should meet the requirements. Reference solution 20μl, into the liquid chromatograph, adjust the sensitivity, the principal component peak height of about 20% to 25% of full scale; then the precise amount of the test solution and reference solution 20μl, injection liquid chromatograph, record the chromatograms to 2 times the peak retention time. Test solution chromatogram as significant impurity peaks, a single impurity peak area no larger than the reference solution 0.4 times the area of ​​the main peak (0.4%), the impurity peak area no larger than the reference solution and the main peak area of 0.8 times (0.8%).
Drying of this product with silica gel desiccant, vacuum drying to constant weight, weight loss shall not exceed 0.5% (Appendix Ⅷ L).
Residue on ignition to take this product 1.0g, according to the determination (Appendix Ⅷ N), no residue left over 0.1%.
Heavy metals residue left over residue on ignition under, according to the determination (Appendix Ⅷ H Second Law), containing heavy metals must not exceed twenty millionths.
Arsenic take this product 1.0g, calcium hydroxide 1.0g, mix, add water, stir, after drying, the first small fire burning so carbonized, and then at 500 ~ 600 ℃ ignition completely gray, immediately put in an ice bath in let cool, add 5ml of hydrochloric acid and water, 23ml, according to inspection (Appendix Ⅷ J first law), shall meet the requirements (not more than 0.0002%

Allantoin main purpose

1, in medicine: allantoin promote cell growth, accelerate wound healing, the physiological function of keratin, such as softening, anti-ulcer agents, and good healing agents of skin wounds. Can be used to alleviate symptoms and treatment of dry skin, scaly skin disease, skin ulcers, peptic ulcers and inflammation, osteomyelitis, diabetes, cirrhosis of the liver, acne have a better effect.
2, in cosmetics: Because allantoin is an amphoteric compound that binds to a variety of substances to form double salts, with dark, antiseptic, analgesic, anti-oxidation, to keep the skin moisture, moist and soft, is Beauty salons and other cosmetic effects of additives, widely used freckle cream, acne solution, shampoo, soap, toothpaste, shaving lotion, conditioner, astringent, anti-sweat deodorant lotion and other additives. Add allantoin cosmetics with conservation organizations, hydrophilic, water and prevent water distribution and so on; adding allantoin hair cream, hair cream, shampoo, hair has a protective effect, can not forked hair constantly hair; adding allantoin lipstick, creams make the skin, lips soft and flexible, and has a beautiful sheen. Allantoin to promote tissue growth, cell metabolism, soften the cuticle proteins. For example magic care magic lip care moisturizing gentle exfoliating scrub to soften the film, moisturizing and shiny main function is to increase the role of allantoin.
3, in agriculture: allantoin is an excellent plant growth regulator, can stimulate plant growth, wheat, citrus, rice, vegetables, soybeans significantly increase yield, and solid fruit, premature action.

Barium hydroxide Applications

Synthetic phenolic resin as a catalyst, the polycondensation reaction is easy to control, a resin obtained low viscosity, fast curing, easy to remove the catalyst. Reference to the amount of 1% to 1.5% phenol. The catalyst may also be used as a water-soluble urea-modified phenol-formaldehyde adhesive, the cured product was a pale yellow, resin remaining in the barium salt of divalent and does not affect the chemical stability of the dielectric.
Reagents for the analysis, but also for the separation and manufacture of precipitated barium sulfate salts, measuring carbon dioxide in air. Quantitative chlorophyll. Refined sugar and animal and vegetable oils. Boiler water cleaner. Pesticides. Rubber industry.

PRAZIQUANTEL laboratory determination

Method name: praziquantel tablets – praziquantel – High Performance Liquid Chromatography
Applications: The method for determining the content of praziquantel praziquantel tablets using high performance liquid chromatography.
This method is applicable to praziquantel tablets.
Method: the small study sample, internal standard solution dissolved in methanol and then diluted into the HPLC chromatography with UV absorbance detector at a wavelength of 263nm peak area detected praziquantel, calculated its content.
Reagents: 1 methanol
2. Α-asarone
Equipment: 1 Instrument
1.1 HPLC
1.2 column
Octadecylsilane bonded silica as a filler
1.3 UV absorption detector
2 chromatographic conditions
2.1 mobile phase: methanol-water = 10040
2.2 detection wavelength: 263nm
2.3 column temperature: room temperature
Preparation of internal standard solution 1: Sample Preparation.
Precision Weigh α-asarone amount, dissolved in methanol and diluted into each 1mL solution containing 0.4mg, namely the internal standard solution.
Preparation of 2 reference solution
Precision Weigh praziquantel reference about 100mg, set 10mL volumetric flask, precision internal standard solution 5mL, and shake to dissolve, diluted with methanol to the mark, shake, is the reference solution.
Preparation of the test solution 3.
20 to take the test, accurately weighed, small study, accurately weighed amount (approximately equivalent to praziquantel 100mg), set 10mL volumetric flask, precision internal standard solution 5mL, and shake to dissolve, dilute with methanol to scale, shake, that is, the test solution.
Note: “Precision Weigh” means to check the weight should be accurately referred to take the weight of one-thousandth. ‘Precise amount “means the amount of the volume should meet the accuracy requirements of national standards for the volume pipettes.
Steps: precision drawing reference solution and the test solution 10mL, high performance liquid chromatography with UV absorbance detector praziquantel (C19H24N2O2) at a wavelength of 263nm peak area, calculates its content.

povidone iodine information

povidone iodine
Formula (Formula): C6H9I2NO
Molecular Weight (Molecular Weight): 364.95
CAS No:. 25655-41-8
Quality Index (Specification)
Appearance (Appearance): reddish brown or yellow-brown amorphous powder
Content (Purity): a variety of molecular weights
Physical and chemical properties (Physical Properties)
Solubility: PVP is a water-soluble polymer, both miscible with water and can dissolve many alcohols, carboxylic acids, amines, halogenated hydrocarbons and other organic solvents.
Film forming: PVP having very good film-forming properties, PVP was dissolved in certain solvents such as water, methanol, ethanol and the like may be cast or coated film.
Water absorption: PVP with a strong water absorption and moisture retention, commonly used in advanced cosmetics.
Increase in dispersibility and solubility: PVP small molecules have a good dispersion, to prevent mutual aggregation of particles and precipitation. PVP can increase the number of substances
Solubility in aqueous solution.
Complexation: O atoms in the molecule PVP, N atoms are typical ligand atom, it has the ability to complex with some substances, such as iodine, benzene
Class A morpholino and a variety of sulfa drugs.
Effective Iodine 9.0 – 12.0%, an iodine ion% max: 6.6, Heavy metals ppm max: 20, Ash% max: 0.1, nitrogen content% :9.5-11 .5, pH value (10% solution) 1.5 to 5.0 Loss on drying % max: 8.0.
Use (Useage)
PVP excellent surface activity, film, no skin irritation, no allergic reactions and other characteristics of household chemicals, especially in cosmetics,
Application of skin care products, hair care products and cleaning supplies, etc. has broad prospects. If added with PVP of hairspray and mousse persistent stereotypes,
Has good gloss, and because of PVP with some absorbent, smooth and moisturize the hair will not look boring. Plus a PVP
Skin care products, not only a good moisturizing effect, and in the film formed on the surface of the skin to make the skin with the outside world (such as sunlight) separated, played Paul
Protect the skin.
PVP good solubility, Increase soluble, physiologically compatible, bonding capacity and complexing ability of other properties, in the field of medicine and medical health,
Is widely used, can be used as binders, excipients, coating agents, disintegrants, solubilizers, disinfectant, solubilizers, release agent,
Capsule shell, a dispersion stabilizer, film and the like.
Industrial Applications
Adhesives: PVP has a very good solution viscosity, solid glue stick, stamp, band-aid, plaster bandages used as adhesives.
Paints and inks: PVP having excellent dispersibility, the PVP added to the coating to increase the viscosity, improve the coloring power, eliminating
Floating color phenomenon, pigment dispersion and stabilization of the composition, improved gloss, avoid flocculation of the pigment.
The new membrane materials: PVP not only can improve the hydrophilicity of the film, but also by selecting different molecular weight and the amount of PVP
Control, to control the pore size and distribution. Also PVP in drag reduction materials, glass fiber, laser disc, light curing resin, photosensitive materials have applications in areas such as new materials.

Potassium bromide was prepared

By bromine synthetic potassium bromide and potassium hydroxide dissolved in distilled water dubbed electrolyte, electrolytic 24H after the first batch of crude, after every take time 12H crude, crude washed with distilled water to remove the potassium bromide solution, add a small amount potassium adjust PH value of 8, the insulation 0.5H filtered and the clear filtrate was cooled to room temperature in the mold, crystallization, separation, and drying to obtain the product potassium bromate.
Chlorine oxidation
After lime and chlorine bromine chlorine reaction leads to the oxidation reaction to PH value reaches 6-7 reaction terminated. After the slag, and the filtrate was evaporated. Barium chloride solution was added to precipitate barium bromate reaction, the precipitate was filtered after adding an aqueous suspension of potassium carbonate was added to maintain a constant temperature for the metathesis reaction, the crude potassium bromide after repeated washing with a small amount of distilled water was filtered and evaporated to cooling crystallization, separation, drying, crushed to obtain edible products of potassium bromate.
Bromide – potassium hydroxide method
With bromine and potassium hydroxide as the industrial raw material, with 1.4 times the mass of water to prepare a solution of potassium hydroxide was dissolved, stirring constantly pass into bromine. When bromine be added to a certain number, that is a white crystalline precipitate to obtain crude potassium bromate.
Continue adding bromine, until the liquid is pink so far. In bromine, while constantly adding cold water to the solution, in order to prevent overheating caused by bromine volatilization losses. Repeated recrystallization, filtration, drying, and then dissolved in deionized water, and add a small amount of potassium hydroxide to remove excess bromine synthesis, recrystallization once, finally remove the crystallization, drying derived products.

Oxalic acid specific uses

Complexing agents, sequestering agents, precipitating agents, reducing agents. Analysis for the test and the measurement of beryllium, calcium, chromium, gold, manganese, strontium, thorium and other metal ions. Microscopic analysis of test microcrystalline sodium and other elements. Precipitation of calcium, magnesium, thorium and rare earth elements. Calibration standard solution of potassium permanganate and cerium sulfate solution. Bleach. Help agent. Also be used to remove rust in the construction industry on the clothes before brushing the wall paint, because the walls should be painted a strong alkaline oxalate addition of alkali.
Pharmaceutical industry for the manufacture of chlortetracycline, oxytetracycline, tetracycline, streptomycin, borneol, vitamin B12, phenobarbital and other drugs. Printing and dyeing industry as chromogenic help agent, bleach, pharmaceutical intermediates. Plastics industry for the production of polyvinyl chloride, amino plastics, urea-formaldehyde plastics. [2]
The catalyst used for the synthesis of phenolic resin, mild catalytic reaction, the process is relatively stable, the longest duration. Oxalic acid in acetone solution which catalyze the curing reaction of the epoxy resin, to reduce the curing time. Also used as a urea-formaldehyde resin, melamine formaldehyde resin pH adjusting agent. Also added a water-soluble polyvinyl formal adhesives in improving drying speed and bonding strength. Urea-formaldehyde resins are also used as a curing agent, a metal ion chelator. Starch can be used as an oxidizing agent KMnO4 adhesive accelerator to accelerate the rate of oxidation and shorten the reaction time.
As a bleaching agent
Oxalic acid is mainly used as a reducing agent and bleach for the production of drugs such as antibiotics and borneol and refining rare metals solvents, dye reducing agent, tanning agent.
Oxalic acid is also used cobalt – molybdenum – washing and bleaching of textiles production of aluminum catalyst, metal and marble.
For metal surface cleaning and treatment, extraction of rare earth elements, textile, leather processing, preparation of catalysts.
As a reductant
In organic synthesis industry is mainly used in the production of hydroquinone, pentaerythritol, cobalt oxalate, nickel oxalate, gallic acid and other chemical products.
Plastics industry for the production of polyvinyl chloride, amino plastics, urea-formaldehyde plastics, paint and other films.
Industrial base for the manufacture of dyes, such as light green.
Dyeing industry can replace acetic acid, used as a pigment dye color help agent, bleach.
Pharmaceutical industry for the manufacture of chlortetracycline, oxytetracycline, tetracycline, streptomycin, ephedrine.
In addition, oxalic acid can be used for the synthesis of various oxalate, oxalate and oxamide and other products, and to diethyl oxalate and sodium oxalate, calcium oxalate, such as the largest output.
As mordant
Oxalic acid can be used for antimony mordant, ferric ammonium oxalate is printed blueprint Pharmacy.
Descaling function
Oxalic acid is used to rust. However, be careful when using oxalic acid has a strong corrosive stainless steel. High concentration of oxalic acid is also susceptible to corrosion hand. And the resulting large solubility of the acid oxalate, but has some toxicity. When using, do not eat or drink on the line. After contact with skin oxalic acid, should be promptly cleaned with water.
Chemical agents to sell the store to buy a bottle of acid, take some paired with warm water solution, wipe the paint on rust stains. Then rub with metallographic sandpaper, and finally spray paint. General store selling oxalic acid also sell some medical equipment, glassware.

copper 8-hydroxyquinoline information

Basic Information
[Chinese name] hydroxyquinoline copper; 8 – hydroxyquinoline copper
[Chinese alias] bis (8 – hydroxy-quinolyl) copper
[English name] oxine-copper; copper 8-hydroxyquinoline
[English Name] Bis (8-hydroxyquinolinato) copper (II); Copper (II) Bis (8-hydroxyquinolinate); Oxine-Copper
[CAS No. 10380-28-6]
[MF] C18H12N2O2Cu
【Molecular Weight】 351.84
[Purity] ≥ 98%
[MDL No.】 MFCD00067392
2 Characters
Yellow-green crystalline powder, odorless, tasteless, non-volatile, no deliquescence, flame retardant, black decompose at higher temperatures, insoluble in water and most organic solvents, slightly soluble in quinoline, pyridine, glacial acetic acid, chloroform, weak , soluble in acid, alkali case decomposition.
Industrial green or brown solid. The nature of the general stable, but decompose at high temperatures deterioration.
Three physical parameters
Solubility: 20 times fully dissolved in glacial acetic acid
4 Quality Specifications
Purity: ≥ 98%
Loss on drying: ≤ 0.5%
Hydrochloride: ≤ 0.01%
Sulfate: ≤ 0.1%
5 Instructions for use
Mildew; pesticides, pharmaceuticals synthesis of metal corrosion inhibitor;
Used as a fungicide in agriculture. Also used as rope, wire, leather, vinyl mildew.
By 8 – hydroxyquinoline sulfate derived role.
6 Storage Transportation
Dark dry and ventilated place
UN number: UN3077