Acidity take this product 1.0g, add water 100ml, fully shaking determination (Appendix Ⅵ H) according to the law, pH value should be 5.0 to 6.5. Transmittance solution to take the product 1.0g, plus 1mol / L hydrochloric acid solution 20ml dissolved, according to spectrophotometry (Appendix Ⅳ A), measured at a wavelength of 430nm light transmittance of not less than 98.0%. Chloride take the goods 0.50g, after adding dilute nitric acid to dissolve 10ml, add water to make into a 50ml, dispensing 25ml, check (Appendix Ⅷ A) according to the law, compared with standard control solution made of sodium chloride solution 5.0ml, not thicker (0.02%). Sulfate take the goods 0.70g, add dilute hydrochloric acid and shake to dissolve 5ml, add water to make into a 40ml, according to inspection (Appendix Ⅷ B), 5ml compared with standard potassium sulfate solution 1.4ml dilute hydrochloric acid control solution made not more concentration (0.02%). Other amino acids take the goods, plus 1mol L hydrochloric acid solution / solution made from 10mg per 1ml, thin layer chromatography (Appendix Ⅴ B) test, learn the solution 2μl, points on silica gel G plate to positive butanol – water – acetic acid (5:2:1) as the agent, after the commencement of dried, sprayed with acetone solution (1 → 50) ninhydrin, dried at 80 ℃ 10 minutes and immediately view, in addition to the main spots, shall not significant other spots. Drying of the product, dried at 105 ℃ 3 hours, less weight loss should not exceed 0.2% (Appendix Ⅷ L). Residue on ignition to take this product 1.0g, according to inspection (Appendix Ⅷ N), no residue left over 0.1%. Iron salt residue on ignition key under the residue left over, add 1ml of nitric acid, evaporated on a water bath, add dilute hydrochloric acid 4ml, after tepid dissolved, moved to 50ml of Nessler tube, according to inspection (Appendix Ⅷ G), compare and contrast 1.0ml solution made with standard iron solution, not deeper (0.001%). Heavy metals in the product 1.0g, according to inspection (Appendix Ⅷ H Third Law), containing heavy metals should not exceed ten parts per million. Arsenic take this product 2.0g, dissolved in 23ml water, add 5ml of hydrochloric acid, check (Appendix Ⅷ J First Act) law, shall comply with the provisions of (0.0001%).
L-Citrulline MSDS
1 Basic information
Chinese name: L-citrulline, citrulline
Chinese alias: L (+) -2 – amino-5 – urea acid, urea, amino acid
English name: L-Citrulline; H-Cit-OH; L-Cit-OH
English Name: (S)-2-Amino-5-ureidopentanoic acid
Purity: ≥ 98%
CAS: 372-75-8
Molecular formula: C6H13N3O3
MW: 175.2
2 Characters
White crystalline powder; Solubility in water: 200 G / L (20 ° C), soluble in methanol and ethanol.
Three physical parameters
Melting point: 215 ℃
Specific rotation: +25.0 ~ +27.0 ° (c = 8, 6N HCl)
Loss on drying: <0.5%
Residue on ignition: <0.1%
Heavy metals: <20 ppm
Refractive index: 26 ° (C = 8, 6mol / L HCl)
4 Use Description
Enzymatic synthesis of NO from L-arginine production of NO, L-citrulline are intermediates.
5 storage conditions
2-8 ° C preservation
6 Hazard statement
Dangerous code: Xi
Hazard Class: R36/37/38
Security Level: S24/25-36-26
Hyaluronic acid Details
Glycosaminoglycans (formerly called mucopolysaccharides, glycosaminoglycans and acidic polysaccharides) in the structure of the simplest kind, it is by repeating disaccharide units
GlcUA-β (1 → 3)-GlcNAc, with β-1, 4 glycosidic bond together. In the body, often in free form or covalently (proteoglycan complexes) in the form of complexes present.
Surface molecules which contain a lot of hydrophilic groups, the body itself can absorb 1,000 to 10,000 times the product water, the water for maintaining the loose connective tissue is important; HA while a strong viscosity of the vitreous humor and joint having Run wet and protection; still promote wound healing.
HA is present in the extracellular matrix of connective tissue of animals. Among them, the cattle vitreous, human umbilical cord and rooster combs are commonly used material extracted HA. HA is widely used in cosmetics, artificial joint, surgical lubricants and other products. The U.S. Food and Drug Administration (FDA) approved in 2003 through the use of injection repair fine lines.
Glycine Physical and chemical properties
White monoclinic or hexagonal crystals or white crystalline powder. Odorless, has a special sweetness. The relative density of 1.1607. Melting point 248 ℃ (decomposition). pK’1 (COOH) is 2.34, pK’2 (N + H3) is 9.60. Soluble in water, solubility in water: 25 ℃ when 25g/100ml; 50 ℃ when 39.1g/100ml; was 54.4g/100ml 75 ℃ while; 100 ℃ when 67.2g/100ml. Extremely difficult to dissolve in ethanol, at approximately 100g of anhydrous ethanol to dissolve 0.06g. Almost insoluble in acetone and ether. Reaction of the hydrochloride salt with hydrochloric acid. pH (50g / L solution, 25 ℃) = 5.8 ~ 6.4
Quality standards HGB 3075-79
Molecular weight 75.07
Simple structure NH2CH2COOH
Specification consumption of raw materials consumption quota, kg / t
1, TCA TCA 95% of France 1600
880 industrial grade ammonia
Methenamine 98% 350
Ethanol 95% 1100
2, Strecker Formaldehyde 70% 114
Sodium cyanide 70% 930
Ammonium chloride 70% 1020
Barium hydroxide 80% 1430
Sulfuric acid 90% 725
Glycine has a unique sweet taste, can ease acid, alkaline taste, masking the bitter taste of saccharin in food and enhance the sweetness. If an excessive amount of human intake of glycine, not only can not be absorbed by the body, and will break the balance of the body’s absorption of amino acids affect the absorption of other amino acids, leading to nutrient imbalances and affect health. Glycine as the main raw materials to produce milk drinks, normal growth and development of young people and children can easily adversely affected.(Supplies:http://www.lubonchem.com/)
Glutathione Application
Glutathione has a broad spectrum detoxification, not only for drugs, but also can be used as functional food base in the anti-aging, enhance immunity, anti-tumor and other functional foods widely used.
Clinical drug
Has developed a human glutathione drug widely used in clinical, in addition to the mercapto group using its chelate heavy metals, fluorides, mustard gas poisoning, etc., but also for use in hepatitis, hemolytic disease and keratitis, cataract and retinal diseases such as drug therapy or adjuvant therapy. In recent years, Western scientists, especially Japanese researchers found that glutathione inhibit HIV function.
New research also shows that, GSH can correct acetylcholine, cholinesterase imbalance, played anti-allergic effects, but also to prevent skin aging and pigmentation, reduce the formation of melanin, the skin antioxidant capacity and to improve skin luster, in addition , GSH is also a very good effect in the treatment of diseases of the cornea and improve sexual function.
And vitamin C in combination with
In addition, vitamin C is also an important in vivo antioxidant. Since vitamin C can reversibly hydrogenation or dehydrogenation, the vitamin C has many important roles in vivo redox reaction. For example, many enzymes reactive group is a thiol group (-SH),-SH vitamin C can be maintained in the reduced state to maintain enzyme activity; vitamin C allow oxidized glutathione into reduced glutathione (GSH ), so that hydrogen peroxide (H2O2) to restore the body’s metabolism; Vitamin C also protects vitamin A, E and some B vitamins from oxidation. Therefore, the use of glutathione, vitamin C and used, to improve their effectiveness.
Food
Adding glutathione may play an unexpected role
1, added to pasta, you can play a role in the reduction. Not only shorten the manufacturing time for the bread to the original half or one-third, a significant improvement in labor conditions and serve to strengthen the role of food and nutrition, and other functions.
2, add it to yogurt and infant foods, the equivalent of vitamin C, can play a role in stabilizing agent.
3, which was mixed into the fish cake, and prevents the color deepened.
4, add the meat and cheese and other foods with enhanced flavor effect.
gamma Polyglutamic Acid Applications
- PGA and its derivatives molecular weight ranging from 50,000 to 2 million Daltons range, so they can be widely used in the food industry, cosmetics, health care, water treatment, waste water treatment, hygiene products, medical and hydrogel glue and other fields.
· Health – Osteoporosis who favor the absorption of calcium.
· Pharmaceutical – release of the drug carrier, hemostatic agents, soft tissue fillers. .
· Cosmetics – as a skin moisturizer to improve the quality of care, as a whitening agent with a long-lasting anti-wrinkle properties.
· Polyglutamate advantage for the cosmetics industry is non-toxic, biodegradable and degradation of the skin nutritious high-end products.
· Fully applicable to all skin conditions, and provide superior HA (hyaluronic acid) and collagen-lasting moisturizing effect
· Requires only a very low concentration, thereby reducing cost.
· – PGA derivatives having excellent strength, transparency and flexibility.
γ-poly-glutamic acid can be used in skin care products, shampoo, hair cream, shaving cream and lipstick.
1, γ-γ-PGA Hydrogel poly-glutamic acid and γ-PGA super-hydrophilic and water-holding capacity
When diffuse flooded in the soil, the plants will root hair surface to form a thin film, not only has the function of protecting the root hairs, it is the soil of nutrients, the best delivery platform hairs close contact with moisture, can be useful to improve the efficiency of fertilizer dissolution, storage, distribution and absorption. Prevent sulfate, phosphate, oxalate precipitation effects and metal elements, so that the crop can more effectively absorb soil phosphorus, calcium, magnesium and trace elements. Promote the development of crop roots and strengthen resistance.
2, γ-γ-PGA Hydrogel poly-glutamic acid and γ-PGA balanced soil pH
Acid, alkali with excellent buffering capacity, which can effectively balance the soil pH, avoid long-term use of chemical fertilizers caused by acidic soil.
3, γ-polyglutamic acid is γ-PGA Hydrogel and γ-PGA precipitate toxic heavy metals can be combined
For Pb +2, Cu +2, Cd +2, Cr +3, Al +3, As +4 and other toxic heavy metals have excellent chelating effect.
4, γ-γ-PGA Hydrogel poly-glutamic acid and γ-PGA can enhance the ability of plant disease resistance and stress tolerance
Integrated plant nutrition, soil water activity ingredients, symptoms may enhance resistance by the soil-borne plant pathogens caused.
5, increase production
Make tea, fruits, vegetables and other agricultural products rapidly increase production, increase production up to 10-20%
Ferrous Fumarate Function
1, absorption speed, biological titer, can promote growth and improve feed efficiency, alternative or partial substitute for inorganic iron
2, a variety of enzymes involved in the generation, activation, enhance immune function, improve stress resistance and disease resistance
3, in the intestinal absorption rate of ferrous sulfate equivalent multiples do not interfere with the absorption of other elements, and no other metal elements antagonism
4, and various nutrients, antibiotics, good compatibility, a synergistic effect. Can effectively prevent the destruction of vitamin inorganic iron and other active substances
5, can effectively prevent iron deficiency anemia and complications
Diacerein MSDS
Product Name: Diacerein English name: Diacerein
Molecular formula: C19H12O8 Molecular Weight: 368.29
CAS Number :13739 -02-1
Chemical name: 4,5 – diacetoxy-9 ,10 – dioxo -9,10 – dioxo– anthracene carboxylic acid
Description: orange-yellow long needles (acetone crystallized orange, yellow crystalline methanol).
Pharmacological effects
This product is an important osteoarthritis IL-1 inhibitors. After cell experiments and animal experiments confirmed: it can induce cartilage formation, has analgesic, anti-inflammatory and antipyretic effects; does not inhibit prostaglandin synthesis; osteoarthritis can delay disease progression role. Toxicology: mice and rats the maximum tolerated dose of a single person with more than 190 and 410 times the dose, the maximum tolerated dose over a dog person (dose calculation according to body surface area) with a dose 600 times subacute, chronic and fetal toxicity testing, fertility testing, perinatal and postnatal toxicity test, carcinogenic and teratogenic tests show that the drug has a good safety profile.
Drug interactions
Laxatives and the drug should not be taken together. Taking to improve intestinal transit and (or) when the nature of the drug intestinal contents, forbidden to take the drug. To improve the bioavailability of diacerein should be avoided while taking containing aluminum hydroxide and (or) magnesium hydroxide drugs. After taking diacerein increased use of antibiotics and (or) the likelihood of a patient suffering from chemotherapy enterocolitis, as antibiotics and chemotherapy affect intestinal flora.
Adverse reactions
Mild diarrhea is the application of the drug treatment of the most common side effects (incidence rate of about 7%), usually in the first few days after treatment, the appearance will automatically disappear with continued treatment in most cases. Epigastric pain 3-5% incidence of nausea or vomiting less than 1%. Taking the drug occasionally cause urine color yellow, which is a characteristic of the goods, without any clinical significance.
Taboos
This product can not be used in patients with known allergy or diacerein have allergies anthraquinone derivatives. Patients there had intestinal discomfort (especially irritable colon), we must consider the relative risks and benefits of using the drug.
Product specifications 50mg
Dosage
Long-term treatment (less than 3 months): 1-2 times a day, every one, after meals. Since taking the first two weeks of the drug may cause mild diarrhea, it is recommended that in the first four weeks of treatment a day after dinner orally. After the adaptation of the drug in patients, the dose should be increased to two times a day, after meals orally. Doctors should be determined based on the efficacy of treatment, but treatment should not be less than three months. In clinical trials, patients have been taking this product for 2 years in a row without any security issues. If the treatment requires long-term treatment in combination with other drugs, should be carried out every six months full time, including blood and urine tests, including liver enzymes. Due to the slow onset of the goods (2-4 weeks after treatment markedly) and good gastrointestinal tolerability, suggestions can be combined with other analgesics and non-steroidal anti-inflammatory drugs administered during the first 2-4 weeks Application.
【Storage】
Closed ,15-25 ℃ preservation.
[Note]
1 Plenary affect renal function does not Diacerein pharmacokinetics, it is recommended in this case (creatinine clearance <30 mL / min) to reduce the dose. Diacerein after meals can increase its absorption rate (about 24%); on the other hand, severe malnutrition would reduce the bioavailability of diacerein. Side reactions (e.g., acceleration of intestinal transit) and the amount of the direct incidence of unabsorbed on diacerein, food intake in fasted or less when using this service will increase the incidence of side effects.
2 Although animal experiments did not show that the goods have any reproductive or fetal toxicity, but the drug should not be taken during pregnancy. Meanwhile, lactating women should not take this drug, because there was a small amount of diacerein report into breast milk due to derivatives.
3 is not available for children under 15 years of age, because this age group has not conducted any clinical trials.
4 More than 70 years of age and with severe renal insufficiency (creatinine clearance 10-30 mL / min) in elderly patients required dose in half.
Beta-glucan introduction
White or light yellow powder
【Melting point】: 229 ~ 233 ℃
There are special scent-soluble: about 50% of solubility with precipitation.
[Species]: oat glucan, yeast glucan, Ganoderma dextran, dextran mushrooms, Agaricus glucan, mushroom glucan, maitake dextran, dextran versicolor, monkey Head mushroom glucans.
[Active ingredient]: Beta 1,3-1,6 Glucan
Quality standards: [Source]: Beta-glucan present in a variety of crops organisms yeast, fungus, mushrooms, cereals, etc.. Yeast Beta-glucan is mainly present in the yeast cell wall, yeast bread yeast, brewer’s yeast and so on.
Beta-glucan, Beta Glucans
[Medicinal]: extracted from natural yeast Beta-1, 3D glucan ingredient has great enhanced immunity effect. This glucan activated cells will stimulate non-specific host defense mechanisms, so the application in cancer, infectious disease and trauma treatment by the attention. Special steps to extract and endotoxin-free β-1, 3 – glucan in the U.S. FDA has determined is a safe substance, can be added in the general food, many reports indicate that mice oral yeast β-1, 3 – Portugal glycans strong increase phagocytosis of peritoneal cells of antimicrobial. Furthermore, there are clear dextran radical, radiation, dissolving cholesterol and preventing hyperlipidemia in viral infections caused by resistant, fungi, bacteria and the like. Currently yeast glucan has achieved industrialization, such as Angel Yeast glucan.
BCAA function
Branched chain amino acids as a nitrogen carrier, other auxiliary muscles required for the synthesis of amino acid synthesis, it simply, it is a simple amino acid synthesis process complex whole muscular tissue. Thus, branched-chain amino acids to stimulate insulin production, the main role is to allow the insulin to be absorbed blood glucose in muscle and as an energy source. Insulin also promotes the generation of muscle uptake of amino acids. Both the synthesis of branched chain amino acids, but also anti-catabolic effect, because they can significantly increase protein synthesis, promoting the release of related hormones such as growth hormone (GH), IGF-1 (insulin-like growth factor-1) and insulin and help testosterone in maintaining a reasonable / cortisol ratio.
Branched-chain amino acid also has a very good resistance to decomposition, because they help prevent the loss of muscle protein breakdown and, for those which are in the stage before the diet is very important. In this calorie intake is relatively low, it is strongly recommended to use branched-chain amino acids, proteins together because this time because of the decline in the rate of protein breakdown increases, the same as when you eat protein is digested and absorbed, hydrolyzed protein is broken down into simple soluble substances such as peptides and amino acids, or risk losing muscle.